Pushing The Limits

This week on "Pushing the Limits" join me on this journey through cellular pathways and longevity as I delve into the inner workings of cells and their impact on your overall well-being. We start by unraveling the AMP-activated protein kinase (AMPK) pathway, responsible for regulating metabolism and maintaining cellular balance. We explore how AMPK senses energy levels and its activation benefits for cellular health and energy conservation. We then compare AMPK with another key player, mTOR, and discuss their roles in cellular health and highlight the differences between these pathways and their contributions to longevity. We will look at Autophagy, the cellular cleansing process, emphasizing its significance and its connections to both AMPK and mTOR pathways. The video concludes by discussing how balancing AMPK and mTOR pathways can lead to a longer and healthier life, touching on the secrets of healthy aging, autophagy-inducing supplements and the drug Rapamycin.   Personalised Health Optimisation Consultin

In this very funny, warm and enlightening episode with the very funny and skilled teacher, strength and conditioning coach, Phd candidate, author and broadcaster Craig Harper is all about understanding what drives your behaviours and how to get your brain to behave. We go deep into meta cognition Metacognition refers to the awareness and understanding of one's own thought processes, cognitive abilities, and the strategies used for learning or problem-solving. It involves thinking about one's thinking, reflecting on one's cognitive processes, and having the ability to monitor and control one's mental activities. At the end of the day, we all generally know what is good for us and what isn't - why then don't we always do the 'right thing", eat the right food, sleep when we should, exercise appropriately In this episode Craig shares in his very light hearted and funny way some very serious issues that we all face. How to actually do what we want to do How to stop our brain sabotaging our activities How to

In this weeks episode of "Pushing the Limits" I interview one of the world's leading phytochemical and nutrigenomics researchers who specializes in sulforaphane.  Todays episode is all about improving cellular health, the core of health, and how activating the Nrf2 pathway through such phytonutrients like Sulforaphane (the precursors of which Glucoraphanin and Myrosinase) are found in Broccoli sprouts and other cruciferous veggies.  You will learn: How sulforaphane upregulates the Nrf2 pathway  How the Nrf2 pathway acts as a master switch, turning on over 250 genes and impacting thousands of enzymes in their function.  How the Nrf2 pathway upregulates the cells own intelligent endogenous antioxidant systems  Why just throwing a bunch of antioxidants into the body doesn't work in quenching oxidative stress The impact of upregulating Nrf2 in relation to the gut  How it has system wide implications  Why probiotics don't colonize the gut like you think they do How probiotics (or certain strains) c

This week on "Pushing the Limits" I talk Mindset, resilience, the life of an athlete with the indomitable Tiffanee Cook - boxer, sexual abuse survivor, business owner, podcaster and all round vulnerable/tough chick.   DING, DING, DING... No turning back now, hands encased in leather, mouth guard in and the world and everyone else in it faded into the background. Sights, sounds, thoughts, stories... gone. Blows, danger, failure, truth... standing toe to toe, bearing a soul not yet seen.8pm October 27, 2012   ROUND 1 Was this the first time she had truly 'let go', 29 years in? Over in both a heartbeat and yet an eternity rolled into one. Terror, adrenaline, fear, courage, isolation, trust, visibility and uncertainty. Yet ironically, a certainty she had never-before experienced.   'Letting go' wasn't what she'd dreamt it to be. Emerging with both hands now free to grab hold of a whole new reality. Perhaps she wasn't truly born in 1983, but rather in a ring in 2012. The referee clutched that now free left hand an

In this episode of "Pushing the Limits" I talk to Dr Rob Silverman, Chiropractor, clinical nutritionist, author, international speaker and functional medicine practitioner, founder of Westchester Integrated Health about the gut. Your microbiome is is the key to your immune system, over 80% of your immune system is in the gut.  We do a deep dive into: What is a healthy microbiome SIBO Leaky Gut and how to heal it Gall bladder health, pancreatic enzymes and the role of stomach acid. How the gut impacts your mental health How the gut impacts your neurotransmitter production. What short chain fatty acids are All about probiotics How to get rid of parasites, bacteria and viruses Foods to embrace and what to avoid We talk the latest on bioavailable peptides and  cutting edge longevity insights and much more. If you are having gut issues, autoimmune issues, mood and behavior issues, hormonal issues, bloating, IBS, IBD, Crohns disease, autism, alzheimers or neurodegeneration then this is the  episode for you! Dr R

In this weeks episode I sit down with Dr Ben Weitz, a brilliant chiropractor and functional medicine practitioner and gut health expert. Get ready for an enlightening one-off podcast episode that delves into the intricate world of gut health and its profound impact on your overall well-being. Join us as we sit down with Dr. Ben Weitz, an expert in Functional Medicine, to explore a wide range of fascinating topics that are essential for your health journey. In this special podcast episode, we'll be covering:  SIBO Demystified: Understand what Small Intestinal Bacterial Overgrowth (SIBO) is, how it affects your health, and the strategies to overcome it. The Power of Bile: Discover the crucial role of bile not only in digestion but also as an antimicrobial agent and how it can help combat SIBO. Microbiome & Mood: Uncover the profound connection between your gut microbiome and the neurotransmitters in your brain, shedding light on the influence of gut health on mood and behavior. Gut-Brain Axis: Learn about

In this weeks episode I have the world leading expert on NITRIC OXIDE to guest Dr Nathan Bryan. Dr Bryan has published over 100 scientific papers on Nitric Oxide and is the author of FUNCTIONAL NITRIC OXIDE NUTRITION alongside 4 other books. Dr Bryan has made many seminal discoveries in the field. These discoveries and findings have transformed the development of safe and effective functional bioactive natural products in the treatment and prevention of human disease and provide the basis for new preventive or therapeutic applications. What does Nitric Oxide do in the body? Nitric oxide or NO is considered one of the most important molecules produced in humans. This simple molecule controls oxygen and nutrient delivery to every cell in the body, it regulates cellular communication and even has anti-microbial properties that protect our body from invading pathogens. In fact, this molecule is so important it was named "Molecule of the Year" by Science Magazine in 1992 and in 1998 a Nobel Prize in Physiology or

As you age, your bones lose density.This leads to osteoporosis,falls and fractures. In this week's episodes I speak to Perry Eckert on bone strength and how to avoid,prevent and reverse bone loss through specific weight training using the "Osteostrong" model.  In this episode you will learn:  How to do a non-invasive, drug-free approach to help improve  bone density and overall skeletal strength. Designed to benefit various age groups and backgrounds, particularly those at risk of osteopenia, osteoporosis, and other conditions related to low bone density. How to use nutrition to optimise your bone health Why balance is also important to consider How pilates and yoga, balance and strength training are part of the picture but why they just aren't enough to stop bone loss How hormones play a role in bone density How muscles help in your bone density strategy Risk factors for Osteoporosis and Osteopenia: Osteoporosis and osteopenia are conditions characterized by a decrease in bone density, which makes bones mor

Ever Wondered how well you were doing on the ageing front. Are the lifestyle interventions, the fitness regime, the supplements, the good foods that you're eating all making a difference to how fast you age? In this interview, Ryan Smith CEO of trudiagnostic takes me through my own personal age report, the exceptional, the good the bad and the ugly it's all here. We discussed DNA methylation, Dunedin pace study, immune age, extrinsic and intrinsic and even how my genes are in relation to  obesity  or whether smoking has been a part of my history (hint I have never smoked but my mum did during pregnancy and you can see that on my DNA methylation - wow) - mind you back then she was told it was healthy to smoke. Grrr.  We look to the future  and why these tests are going to be a crucial  tool in your arsenal of interventions to slow ageing.  By doing these tests regularly you can plot your trends, see how you are doing against your peers, compete against yourself, it's motivating to say the least.  I was super e

This week I have the indomitable Michele Hughes to guest who runs the "Timeless and Ageless" podcast where she interviews leading experts in anti-ageing to entrepreneurship to health and fitness.  Michele has tapped into the extraordinary knowledge of so many exceptional achievers and continues to learn and develop herself and share with her audiences. We both share a passion for longevity, anti-aging, entrepreneurship and learning from the best in the world and in this interview Michele shares her valuable insights. BIO Michele Hughes has 25 years of luxury real estate development experience primarily in resort locations like Las Vegas, Hawaii, Aspen, Baja, Idaho and San Francisco. She created a hospitality division of her real estate development company where many VIP/Celebrities selected her properties for their private vacations. Throughout her successful career Ms. Hughes has been an active spokesperson and volunteer for worthy causes. She is experienced in the media having both produced and anchored TV

This is a powerful episode, its very raw and rather emotional but I have Aleisha Pienaar to guest who shares her story of her Dad who had a heart attack last year at the tender age of 53 and  who was, after being revived,  left fighting for his life in ICU. Aleisha had read my book "Relentless" and  had attended one of my speeches where I talked about my Mum and Dad's stories, It  was in her time of need that these stories became the catalyst  for her to fight hard for her Dad. The ICU team were convinced her Dad would not wake up from the coma and that if he did, after having been without oxygen for 46 minutes, that his life would be not worth living and that the  brain damage would be massive or he would be in a vegetative state. They were told they must take him off life support. Aleisha reached out and I encouraged her to fight, to be vigilant and not to give up when all others had.  A couple of days after they were told to take him off life support her father incredibly, woke up and although his rehab  w

In this weeks episode of "Pushing the Limits" Lisa gets to talk to a world leading anti-aging and longevity expert Dr Bill Lawrence who himself is 77 years old but has the telomere length (we explain what that aging biomarker in the show) of someone in their thirties. Dr. Lawrence has a Jurisprudence Degree (UCLA-Law), an MS in Psychology and a Ph.D. in Nutrition. Since 1990 his focus has been on slowing and reversing human biological aging. He has developed numerous science-based protocols focused on optimal aging for health professionals and individual clients.   Presently Dr. Lawrence is the administrator of two clinical studies to determine if human biological age can be reversed in collaboration with Dr Vladimir Khavinson of the Saint-Petersburg Institute of Bioregulation and Gerontology Dr Lawrence shares in this episode a presentation of the current study data (note the trial is still ongoing) and the exciting proof we can now REVERSE aging and promote long and healthier lives and reduce our risk of mo

In this episode I interview Nutritionist and functional Medicine Clinician, Thiamine Expert Elliot Overton on Thiamine Protocols and nutritional deficiencies and how Thiamine could be a key nutrient that can help in many many diseases from: Multiple Sclerosis Kidney Disease Heart Disease Stroke Parkinson Diabetes Beriberi Anxiety Liver Disease Coeliac Disease Fibromyalgia Peripheral Neuropathy Migraine Chronic Fatigue Syndrome Autism  In this episode you will learn: The basics of Thiamine and how it impacts energy metabolism Why functional Thiamine deficiencies are more common than you think Why it helps is such a plethora or seemingly unrelated conditions How thiamine is at the gateway to two major energy pathways and how it affects mitochondria - the power houses of our cells We discuss the life work of a pioneers in this space Dr Derrick Lonsdale and Dr Chandler and their book Thiamine Deficiency Disease, Dysautonomia, and High Calorie Malnutrition If you are interested to find out more you can get the

In this weeks episode of "Pushing the Limits" we have the incredible Dr Matthew Phillips who calls himself a Metabolic Neurologist. After spending over 15 years studying and working in clinical practice with patients with neurodegenerative conditions and cancer etc he decided to extend. his approach from just using medications to manage the disease by diving into the study of the metabolic dysfunction that underlies many of these ailments or that contributes to these diseases. He uses these Metabolic Strategies as Therapies in Cancer and Neurodegeneration and is and has done various clinical trials using his approach His foremost passion is to explore the potential feasibility, safety, and efficacy of metabolic therapies, particularly fasting and ketogenic diets, in creating alternate metabolic states that enhance neuron bioenergetics and may lead to improvements in not only the symptoms, but also function and quality of life, for people with Parkinson's, Alzheimer's, and a variety of additional neurological

In this week's episode of "Pushing the Limits" I interview the incredible Dr Ross Pelton AKA the Natural Pharmacist. Ross Pelton is a pharmacist, nutritionist, author and a health educator who is widely recognized as the world's leading authority on drug-induced nutrient depletions. He was named one of the top 50 most influential pharmacists in the United States by American Druggist magazine for his work in Natural Medicine. He is the author of 13 books including his latest one which we do a deep dive into today on Rapamycin and longevity science  About the Book and what you will learn about in this episode (Disclaimer: none of this is medical advice, it is for educational purposes only)  Rapamycin, mTOR, Autophagy and Treating mTOR Syndrome We discuss how the prescription drug rapamycin can increase longevity. After the discovery of rapamycin, scientists began conducting experiments in an effort to understand rapamycin's mechanism of action. This led to the discovery of mTOR, which in turn, led to the unders

In this weeks episode of "Pushing the Limits" I get to interview my good friend and world class motivational speaker, NZ speaker of the year Cam Calkoen. Now Cam just happens to have cerebral palsy but he has never let this apparent problem hold him back from anything. From climbing Kilimanjaro to being a world class athlete to becoming one of the most well known and loved inspirational speakers of our time (despite a speech impediment)  Anything he sets his mind to he achieves and in this interviewing his infectious positivity, energy and mindset will blow you away. You can connect with Cam on https://camcalkoen.com/ or on instagram as @camcalkoen  You will come away from this interview, uplifted and empowered and those excuses you told yourself were limiting factors will fade away when you hear his awesome stories   Personalised Health Optimisation Consulting with Lisa Tamati Lisa offers solution focused coaching sessions to help you find the right answers to your challenges.   Topics Lisa can help with: 

In this episode of "Pushing the Limits" I interview the founder and inventor the QRI Laser Bonnie Brandes a former teacher of children with learning disabilities, autism, down syndrome, dyslexia, ADHD, cerebral palsy who discovered the benefit of reintegrating primitive reflexes and the help and relief this bought the children and their families. Bonnie then went on a journey to do it quicker and better and rather than  just using touch and acupuncture she ended up inventing a device to combine low. level cold lasers with sound therapy and acupuncture called the QRI Laser. I have been exploring the use of this device in my mum Isobel's rehabilitation journey as I became aware after studying some of the reflexes she was exhibiting and ways to reintegrate them.   In this episode you will learn: What are primitive reflexes and how they are the building blocks for our neurological development in early childhood and how sometimes these reflexes don't get integrated when they should and the implications of this. W

In this episode I interview the incredible Dr Dave Jenkins, a Bredeson Protocol trained practitioner, GP, Founder of Surfaid International and a man on a mission to help individuals, families, and communities improve health outcomes through effective and achievable evidence based methods. His vision is to resolve the root cause of illness and reduce barriers to true health through education, coaching, and shared care scalable models He is a specialist in cognitive decline.   In this interview you will learn: What contributes to Alzheimers and dementia and neurodegeneration Why you need to understand your metabolic state How to manage your blood sugar and why you should How to reverse diabetes Understanding mold toxicity Why you need a personalised approach to these major disease How lifestyle changes can greatly improve your life, your longevity and health span Why obesity is an inflammagen How Vitamin D and zinc affect Brain health Why we need more health coaches Dr Dave's work with Dr

This week episode of "Pushing the Limits" Lisa interviews internationally recognized expert in the mechanisms of neurodegenerative diseases, Dr. Dale Bredesen.   Alzheimer's disease is one of the most significant global health threats we face today. It is an ailment that, as our population ages, is forecasted to become a worldwide epidemic. To understand the magnitude of the problem, the COVID-19 pandemic has already led to the death of over one million Americans, however, 50 times more of the currently living Americans let alone the rest of the world— nearly 50 million — will die of Alzheimer's disease if effective prevention and reversal are not implemented.    Mainstream medicine would have you believe that it can't be prevented, is untreatable, and is progressive, with most patients not surviving beyond three to eleven years post-diagnosis. After having spent myself 8 years researching brain rehabilitation in the effort to save my mum after an aneursym, stroke, multiple concussions, small vessel ischemic

This week I had a luminary in the longevity and anti-aging medicine field to guest, Phil Micans is the editor of Aging Matters Magazine and Founder of IAS Group for Anti-Aging. He is an expert in many areas of longevity but todays main topic was Bioregulator Peptides, an incredibly exciting continuation to our series on Peptide therapies. A bioregulator peptide is a short chain of amino acids that functions as a regulatory molecule in biological systems. These peptides are typically derived from natural sources, such as organs, tissues, or other biological substances, and they play a role in modulating various physiological processes in the body. Bioregulator peptides are believed to work by selectively binding to specific target cells or receptors, triggering specific cellular responses and signaling pathways. They can act as messengers to regulate and optimize the functioning of various organs and systems. I am super excited about these "Gene Switches" - signalling molecules that help our cells and organs "